Margolis Pauliina M.

Margolis Pauliina M.

USA

Marja Pauliina Margolis, MD, PhD

Current Position: Chief Medical Officer and Vice President Keystone Heart Birthday and Place: June 9, 1955, Joensuu, Finland Nationality: Finnish and USA Family: Married, two children Education: Senior High School of Jyvaskyla
University of Jyvaskyla, Faculty of Physical education, Finland 1975-1981, Master of Physical Education
University of Oulu, Faculty of Medicine, Finland 1981-1985; Bachelor of Medicine 1981, Doctor of Medicine 1985, Registered Physician 1986 Ph.D. (Coronary Physiology) 1987
University of Cincinnati, College of Medicine, USA 1988-1991; postdoctoral fellow
University of Helsinki, Faculty of Medicine, Finland 1992-1994; specialty in internal medicine
University of Edinburgh, Department of Cardiology, Scotland, 1994-1998; Full Registration GMC in UK 1996, interventional cardiology 1998
Stanford Business School, Stanford University, early business development and Executive Management, 2001 Certificates awarded: Young Investigator of the Year 1988 Finnish Society of Cardiology Work experience: Laboratory assistant, Jyvaskyla Central Hospital Summers 1975, 1976, 1981 Junior Lecturer of Physiology, University of Oulu, Finland Summers 1982, 1983, 1984 Internship in Internal medicine, Oulu University Central Hospital 1985 Department of Internal Medicine, Lahti Central Hospital, Finland 1996 Compulsory General Practioner 2 Central Health Care Center of Oulu 1986 Junior Lecturer, Department of Physiology, Oulu, Finland 1987 Clinical Fellow, Department of Internal Medicine, University of Helsinki 1987 Post-Doctoral Fellow, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA 1988- 1991 Clinical Fellow (Registrar), Department of Internal Medicine and Cardiology, Helsinki University Central Hospital 1993-1994 Research Fellow and Honorary Cardiac registrar, Department of Cardiology, Western General Hospital, University of Edinburgh, UK 1994- 1997 Consultant: TransVascular, Inc. 1998 Point BioMedical, 1998 PharmaSonics, Inc. 1998 Medical Director, PharmaSonics, Inc. 1999-2001 Consultant: American Bioscience 2001 Target Therapeutics 2001-2002 VasConnect 2001-2002 Volcano Therapeutics 2001 Volcano Corp 2002 Medical Director VP of Scientific Affairs and Medical Director 2006-2008 VP of Scientific Affairs and Chief Medical Officer 2009-2012 Consultant Chief Medical Officer and VP, Keystone Heart 2012-2015 Chief Medical Officer and VP 2015 –
Teaching experience: Human Physiology for medical students terms 1981-1985 Cardiology for Medical student 1988-1991, USA Cardiology for Medical student, 1995-1997, UK 3 Main research, presentations, and publications: Coronary physiology The cardiovascular effects of steroids and endurance training The effect of blood oxygen affinity on cardiac performance Acute pancreatitis and hemodynamic shock Microembli and heart failure Vascular effects of Laser angioplasty Lipid lowering drugs Cardiac death due to Ca-antagonist overload Intravascular ultrasound Tissue Doppler Imaging Intravascular ultrasound tissue characterization Vulnerable plaque and risk of acute heart attack Ultrasound signal processing Interventional cardiology; restenosis and sonotherapy Coronary hemodynamics Brain injury; cardiovascular procedures related risk of stroke, neurocognitive decline, and dementia
Articles
(refer to last name listed as Rämö, Moore in citations) 1. Kettunen R, Timisjärvi J, Kouvalainen E, Rämö P and Hirvonen L. Electromechanical delay in the intact dog heart. Int J Card 1985;9:161-171. 2. Kettunen R, Timisjärvi J, Kouvalainen E, Rämö P and Linnaluoto M. The automatic computation of pressure derived maximal shortening velocity (Vmax) of the unloaded contractile element in the intact canine heart left ventricle. Acta Physiol Scand 1986;127-:467-475. 3. Kettunen R, Timisjärvi J, Rämö P, Kouvalainen E, Heikkilä J, Hirvonen L. Time constants of isovolumic pressure fall in the intact canine left ventricle. Cardiovasc Res 1986;20:698-704. 4. Rämö P, Kettunen R, and Hirvonen L. The hemodynamic effects of endurance training on canine left ventricle. Am J Physiol 1987;252:H7-H13. 5. Rämö P. Anabolic steroid alter the contractile reserve capacity of the canine left ventricle. Acta Physiol Scand 1987;130:209-217. 6. Rämö P, Kettunen R, Takala T and Hirvonen L. Anabolic steroids alter the hemodynamic effects of endurance training on the canine left ventricle. Pflugers Arch, Eur J Physiol 1987; 410:272-278. 7. Rämö P, Kettunen R, Takala T. The effect of anabolic steroids and endurance training on systolic time intervals in the dog. Acta Physiol Scand 1987;129:543-548. 8. Timisjärvi J, Kettunen R and Rämö P. Mean outflow resistance as a marker of left ventricular afterload. Basic Res Cardiol 1987;82(3):216-225. 4 9. Rämö P. Endurance training, methandienone treatment and the left ventricular function of canine heart. Thesis, University of Oulu, Oulu, Finland. 1987. 10. Rämö OJ, Rämö P and Kiviniemi H. Prostacyclin is released mainly from the splanchnic region during the early phase of acute experimental hemorrhagic pancreatitis in dogs. Digestive Surg 1988;5(2):95-98. 11. Karhunen M, Rämö P, Kettunen R, and Hirvonen L. The cardiovascular effect of deconditioning after endurance training in rats. Acta Physiol Scand 1988;133:307-314. 12. Karhenen MK, Rämö MP, Kettunen R. Anabolic steroids alter the hemodynamic effects of endurance training and deconditioning in rats. Acta Physiol Scand 1988;133:297 13. Rämö OJ, Rämö P, Karhunen M, Kiviniemi H and Kettunen R. Impaired venous return causes circulatory failure in experimental pancreatitis shock in dogs. Intensive Care Med 1989;15(2):111-115. 14. Rämö P, Karhunen M and Rämö OJ. Systolic time intervals during canine acute hemorrhagic pancreatitis. J Surg Res 1989;46:212-215. 15. Rämö MP, Plowden JS, Gabel M, Millard RW and Lathrop DA. Amlodipine, a longacting calcium antagonist drug reduces ischemia-induced ventricular conduction delay in pig hearts. Am J Cardiol 1989;64(17):781-831. 16. Savolainen H, Apaja-Sarkkinen M, Sahlman A, Rämö P and Schröder T. The effect of contact Nd:YAG laser on arterial wall and atherosclerotic plaques. Considerations for angioplasty. Ann Chir Gyn 1990;79:37-41. 17. Takala T, Rämö P, Kiviluoma K, Vihko V, Kainulainen H and Kettunen R. Effects of training and anabolic steroids on collagen synthesis in dog hearts. Eur J Appl Physiol 1991;62:1-6. 18. Rämö MP, Grupp I, Pesola MK, Heikkilä J, Luomanmäki K, Schröder T and Grupp G. Cardiac Clycosides in the treatment of experimental overdose with calcium-blocking agents. Res Exp Med 1992;192:335-343. 19. Takala TE, Kiviluoma K, Kihlström M, Rämö P, Vihko V. Effects of physical training methandienone and their combination on the lysosomal hydrolytic activities in dog heart. Int J Sports Med 1992;13(1):52-55. 20. Rämö MP, Barker-Gear F, Gabel M, Millard RW, Franco RS. Performance of flowregulated myocardium in pigs with normal, low and high blood oxygen affinity (BOA). Adv Biochemistry 1993. 21. Rämö OJ, Lavonen J, Soiva M, Huusari H, Rämö MP, Mokka R. Effects of lovastatin in prevention of restenosis after percutaneous transluminal angioplasty in lower limbs. Int J Angiology 1994. 22. Kearney P, Rämö P, Spencer T, Shaw S, Starkey I, Sutherland G. How important are image distortion artifacts when using mechanical intravascular ultrasound transducers? Br Heart J 1995;73:43. 23. Nieminen M, Rämö MP, Karjalainen M, Viitasalo M, Heikkila J. Serious side-effects of large doses of anabolic steroids in body builders. Eur Heart J 1996 24. Kearney P, Rämö MP, Starkey IR, Shaw TRD, McMurray J, Sutherland GR. A Comprehensive Assessment of the Short Term Reproducibility of Intravascular Ultrasound Quantitation. British Heart Journal 1996. 25. Kearney P, Rämö MP, Spencer T, Shaw TRD, Starkey IR, Sutherland GR. A Study of the Quantitative and Qualitative Impact of Catheter Shaft Angulation in a Mechanical Intravascular Ultrasound System. Ultrasound in Medicine and Biology 1996 5 26. Kearney P, Rämö MP, Spencer T, Shaw TRD, Starkey IR, Sutherland GR. An Analysis of the Reproducibility of Reference Lumen Quantitation with Intravascular Ultrasound in Stented Coronary Arteries. Catheterisation and Cardiovascular Diagnosis 1997 27. T Spencer, MP Rämö, DM Salter, T Anderson, PP Kearney, GR Sutherland, KAA Fox, WN McDicken. Characterization of atherosclerotic plaque by spectral analysis of intravascular ultrasound: an in vitro study with histological and radiological validation. Ultrasound Med Biol. 1997 28. M Pauliina Moore (nee Ramo), Timothy Spencer, Donald Salter, Peter P Kearney, Stuart TRD Shaw, Ian R Starkey, Peter J Fitzgerald, Raimund Erbel, Aleksandra Lange, George R Sutherland, Keith AA Fox. Characterization of coronary atherosclerotic morphology by spectral analysis of radiofrequency signal: An in vitro intravascular ultrasound study with histological and radiological validation. Heart 79:459-67, 1998 29. Spencer T, Ramo MP, Salter D, Sutherland GR, Fox KAA, McDicken WN. Characterization of atherosclerotic plaque by spectral analysis of 30 MHz intravascular ultrasound radiofrequency data. Proc. Of the IEEE Ultrasonics Symposium 1996 . 30. Nailon WH, McLaughlin S, Spencer T, Ramo MP. Comparative study of textural analysis techniques to characterize tissue from intravascular ultrasound. Proc. Of the IEEE International Conference of Image Processing, Switzerland. IEEE Signal Processing Society: USA, 1996. 31. Nailon WH, McLaughlin S, Spencer T, Ramo MP. Intravascular ultrasound image interpretation. Proc. Of the International Conference on Pattern Recognition, Austria. IEEE Computer Society Press: USA, 1996. 32. Ramo MP, Spencer T, Kearney PP, Shaw TRD, Starkey IR, McDicken WN, Fox KAA. The in vitro characterization of red and white thrombus and plasma with different age and composition by spectral analysis of intravascular ultrasound radiofrequency data. 33. Lange A, Palka P, Caso P, Fenn LN, Olszewski R, Ramo MP, Shaw TRD, Nowick A, Sutherland G. Doppler myocardial imaging versus B-mode grey-scale imaging: A comparative in vitro and in vivo study into their relative efficacy in endocardial boundary detection. Ultrasound Med Biol. 1998 34. Komiyama N, Berry GJ, Kolz ML, Oshima A, Metz JA, Preus P, Brisken AF, Moore MP, Yock PG, Fitzgerald PJ. Tissue Characterization of atherosclerotic plaques by intravascular ultrasound radiofrequency signal analysis: an in viro study of human coronary arteries. Am Heart J 140:565-74, 2000 35. Watson, RJ, McLean CC, Moore MP, Spencer, Salter DM, Anderson T, Fox KAAA, McDicken WN. Classification of arterial plaque by spectral analysis of in vitro radiofrequency intravascular ultrasound data. Ultrasound in Med & Bio 26: 73-80, 2000 36. Peter J. Fitzgerald, Atsushi Takagi, M. Pauliina Moore, Motoya Hayase, Frank D. Kolodgie, Doug Corl, Menahem Nassi, Renu Virmani, and Paul G. Yock Intravascular Sonotherapy Decreases Neointimal Hyperplasia After Stent Implantation in Swine. Circulation, Apr 2001; 103: 1828 – 1831. 37. Diethrich EB, Margolis PM, Reid, DB, Burke A, Ramaiah V, et al. Virtual histology intravascular ultrasound assessment of Carotid Artery Plaque Virtual Histology Evaluation (CAPITAL) Study. Journal of endovascular therapy, International Society of Endovascular Specialists 14(5):676-86, 2007. 38. In Vivo Coronary Plaque Classification by Intravascular Ultrasonography: Present Studies with VH IVUS. Margolis P. Medscape CME 2007 6 39. Technology Insight: in vivo coronary plaque classification by intravascular ultrasonography radiofrequency analysis. König A, Margolis PM, Virmani R,Holmes D, Klauss V. Nature Clinical Practice Cardiovascular Medicine (2008) 5, 219-229. 40. Multicenter assessment of coronary allograft vasculopathy by intravascular ultrasoundderived analysis of plaque composition. Sarno G, Lerman A, Bae JH, Schukro C, Glogar D, Margolis PM, Goethals M, Verstrekem S, Bartunek J, Koenig A, Wijns W, Vanderheyden M. Nature 2008. 41. Impact of Gender and Age on In Vivo Virtual Histology–Intravascular Ultrasound Imaging Plaque Characterization (from the global Virtual Histology Intravascular Ultrasound [VH-IVUS] Registry) J. Qian, A. Maehara, G. Mintz, M. Margolis, A. Lerman, J. Rogers, S. Banai, S. Kazziha, C. Castellanos, L. Dani. The American Journal of
Cardiology, Volume 103, Issue 9, Pages 1210-1214 2009. 42. Impact of intramural thrombus in coronary arteries on the accuracy of tissue characterization by in vivo intravascular ultrasound radiofrequency data analysis. Nasu K, Tsuchikane E, Katoh O, Vince DG, Margolis PM, Virmani R, Surmely JF, Ehara M, Kinoshita Y, Fujita H, Kimura M, Asakura K, Sakura Y, Matsubara T, Terashima M, Suzuki T. Am J. Cardiol 2008 Apr 15;101(8):1079-83. Epub 2008 Feb 11. 43. Impact of Intramural Thrombus in Coronary Arteries on the Accuracy of Tissue Characterization by In Vivo Intravascular Ultrasound Radiofrequency Data Analysis. Nasu K, Tsuchikane E, Katoh O, Vince GD, Margolis PM, Virmani R, et al. American Journal of Cardiology, Volume 101, Issue 8, 15 April 2008 1079-1083. 44. Technology Insight: in vivo coronary plaque classification by intravascular ultrasonography radiofrequency analysis. Konig A, Margolis P, Virmani R, Holmes D, Klauss V. Nature Clinical Practice 2008, Vol 5, Issue 4, 219-229. 45. Tissue Characerisation using intravascular radiofrequency data analysis: recommendations for acquisition, analysis, interpretation and reporting. Garcia-Garcia HM, Mintz GS, Lerman A, Vince DG, Margolis PM, van ES GA, Morel MAM, Nair A, Virmani R, Burke A, Stone GW, Serruys PW. Euro PCR on-line March 2009. 46. Synergistic Effect of Cardiovascular Risk Factors on Necrotic Core in Coronary Arteries: A Report From the Global Intravascular Radiofrequency Data Analysis Registry. Garcia-Garcia HM, Serruys PW, Mintz GS, Saito S, Klauss V, Margolis PM, Carlier S, Goedhart D, Schwartz R. JACC Cardiovascular Imaging. Volume 2, Issue 5, 629-636 May 2009. 47. Intravascular ultrasound measures of coronary atherosclerosis are associated with Framingham risk score: an analysis from the global IVUS registry. Marso S, Fruitkin A, House J, Klauss V, Lerman A, Leon M, Nair A, Margolis P, Erbel R, et al. EuroIntervention 2009;5:100. 48. Analysis of the long term effects of drug-eluting stents on coronary arterial wall morphology as assessed by virtual histology ultrasound. Kubo T, Maehara A, Mintz G, Garcia-Garcia H, Serruys P, Leman A, Marso S, Margolis P, Margolis J, de Bruyne B, Leon M, Stone G. American Heart Journal (2010) Vol. 159 Isssue 2, 271-277. 49. The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. Kubo T, Maehara A, Mintz G, Doi H, Katoh O, Wijns W, Rogers J, Margolis P, Moses J, Stone G, Leon M. JACC 2010 Vol. 55, Issue 15, 1590-1597. 7 50. Diabetes mellitus is associated with plaque classified as thin cap fibroatheroma: an intravascular study. Marso S, House J, Klauss V, Lerman A, Margolis P, Leon M. International Society of Diabetes and Vascular Disease 2010 Vol 7, Issue 1 14-19.
Abstracts 1. Hirvonen L, Forsberg S, Tolonen U, Rämö P and Karikoski O. Combined effects of smoking and reduction of oxygen pressure on physical performance. Clin Physiol 1983;3:43 2. Saukko P, Stenbäck F, Rämö P. Effect of anabolic steroids and endurance training on the ultrastructure in canine myocardium. Scandem 1986:42. 3. Rämö P and Kettunen R. The effects of anabolic steroids on cardiovascular adaptation to endurance training. XI Scand Congress of Cardiology, Kuopio, Finland 1987, August 20-21 4. Kettunen R, Karhunen M and Rämö P. Anabolic steroids after the hemodynamic responses to the canine left ventricle. XI Scand Congress of Cardiology, Kuopio, Finland 1987, August 20-21 5. Hirvonen L, Kettunen R, Rämö P and Karhunen M. Nicotine impairs the relaxation of the canine left ventricle. 11th Puijo Symposium, Kuopio, Finland, 1987, August 17- 19. 6. Rämö P, Luomanmäki K, Mäkeläinen A, Karhunen M and Heikkilä J. Digoxin in the treatment of verapamil overdose. Ann Clin Res 1988 7. Millard RW, Rämö P, Dunlap ED, Barker RL, and Franco RS. Hemodynamic response to inositol-hexaphosphate-treatede low-affinity blood. The FASEB j 1989;3(3):3557 8. Dunlap ED, Gabel M, Barker RL, Franco RS and Millard RW. Low oxygen affinity blood attenuates cardiac mechanics dysfunction during restricted oxygen delivery. The Physiologist 1989:32:183. 9. Rämö P, Plowden JS, Gabel M, Millard RW and Lathrup DA. Amlodipine prevents ischemia-induced conduction delay in swine. Circulation (Suppl) 1989;80(4):II-149 10. Dunlap ED, Rämö MP, Barker RL, Franco RS and Millard RW. Hemodynamics and organ flow changes in conscious swine following acute shifts in blood oxygen affinity. The FASEB J. 1990 11. Rämö MP, Lauer MA, Gabel M and Millard RW. Cardiac function during progressive myocardial ischemia in pigs with coronary microembolization. Circulation.(Suppl) 1990;82(4):111-52. 12. Rämö MP, Dunlap ED, Gabel M, Gear R, Franco RS and Millard RW. Low blood oxygen affinity improves cardiac function during regional myocardial ischemia in pigs. JACC 1991; 172(2):144A. 13. Rämö MP, Barker-Gear R, Gabel M, Millard RW, Franco RS. Performance of flow regulated myocardium in pigs with normal, low and high blood oxygen affinity (BOA). 5th Meeting of the International Society for the use of Resealed erythrocytes 1993. 8 14. Rämö OJ, Lavonen J, Soiva M, Huusari H, Rämö MP, Mokka R. Effects of Lovasatin in prevention of restenosis after percutaneous transluminal angioplasty in lower limbs. Annual Meeting of Am College of Angiology, Orlando, USA October 1993. 15. Aarnio P, Rämö MP,, Nieminen M. Effects of levosimendan on myocardial contractility in ischemic myocardium. International College of Angiology Annual Meeting, Helsinki, June 1995. 16. Siltanen T, Aarnio P, Rämö MP, Kaarne M. Pre reactivity of vascular rings to levosimendan. International College of Angiology Annual Meeting, Helsinki, June 1995. 17. Rämö MP, Kearney P, Starkey IR, Shaw TRD, McMurray J, Sutherland GR. Assessment the reproducibility of reference lumen quantitation with IVUS in patients undergoing coronary stenting. 7th Essen-Mayo-Mainz Symposium. May 1995, Essen, FR6. 18. Palka P, Lange A, Sutherland GR, Flemming AD, Fenn L, Bouki K, Rämö MP, McDicken N. Doppler Tissue Imaging: assessment of systolic and diastolic transmural velocity gradients in hypertrophic cardiomyopathy. A new diagnostic index. European Heart Journal , XVIIth Congress of the Euro Society of Cardiology, Amsterdam 1995, vol. 16, 105. 19. Lange A, Palka P, Sutherland GR, Flemming AD, Fenn L, Bouki, K, Wright R, Rämö MP, McDicken N. Doppler Tissue Imaging: assessment of systolic and diastolic transmural velocity gradients in hypertrophic cardiomyopathy. A new diagnostic index. European Heart Journal, XVIIth Congress of the Euro Society of Cardiology, Amsterdam 1995, vol. 16, 298. 20. Kearney PP, Rämö MP, Starkey I, Shaw TRD, McMurray J, Sutherland GR. How reproducible is reference lumen quantitation with intravascular ultrasound in patients undergoing coronary stenting. European Heart Journal, XVIIthCongress of the Eur Society of Cardiology, Amsterdam 1995, vol 16, 203. 21. Kearney PP, Rämö MP, Spencer T, Shaw TRD, Starkey I, Sutherland GR. Assessment of the reproducibility of reference lumen quantitation with intravascular ultrasound in patients undergoing coronary stenting. 68th annual Meeting of Am Heart Association, Anaheim, California 1996. 22. Kearney PP, Rämö MP, Spencer T, Shaw TRD, Starkey I, Sutherland GR. The reproducibility of IVUS measurements I unselected video frames assessed in sequential catheter pullbacks and in separate analysis sessions. 68th annual Meeting of Am Heart Association, Anaheim, California 1996. 23. Kearney P, Rämö MP, Shaw T, Starkey I, McMurray J, Sutherland G. The reproducibility of IVUS measurements I unselected video frames assessed in sequential catheter pullbacks and in separate analysis sessions. Circulation 1995;92:I-78 24. Kearney P, Rämö MP, Shaw T, Starkey I, McMurray J, Sutherland G. Reproducibility of Reference Lumen Quantitation with intravascular Ultrasound in patients undergoing coronary stenting. Circulation 1995;92:I-601 25. Roth T, Koch L, Erbel R, Kearney P, Ramo P, Spencer T, Sutherland G. Development of a system of intracoronary ultrasound based frequency dependant tissue characterization. Proceedings of “Echocardiography 1995”, Rotterdam, The Netherlands. June 1995 9 26. M. Pauliina Ramo, Timothy Spencer, George R. Sutherland, Peter Kearney, Norman W. McDicken, Keith AA Fox. Analysis of unprocessed Intravascular Ultrasound radiofrequency data can Characterize Red and White thrombus of different age. The Journal of Invasive Cardiology “Transcatheter Cardiovascular Therapeutics 1996” 27. M. Pauliina Ramo, Timothy Spencer, Aleksandra Lange, Przemyslaw Palka, AA Fox, George R Sutherland. Can ultrasound texture analysis distinguish between red and white thrombi: A comparative study of intravascular videodensitometric and radiofrequency data. American Heart Journal. Amer. College of Cardiology 1996 28. Nobuyaki Komiyama, Jonas Metz, Peter Presuss, Lars Gullestad, Guy Haywood, Pauliina Ramo, Yock Paul, Peter Fitzgerald. Quantitative tissue characterization of arteriosclerotic plaques and thrombi by intravascular ultrasound radio-frequency analysis. The Journal of Invasive Cardiology “Transcatheter Cardiovascular Therapeutics 1996” 29. Pauliina Ramo, Timothy Spencer, George R. Sutherland, Donald M. Salter, Peter Kearney, David Lamb, TRD, Stuart Shaw, Norman W. McDicken, Raimund Erbel, Peter Fitzgerald. Can radiofrequency data analysis of intravascular ultrasound accurately characterize coronary atherosclerosis? American Heart Journal. Amer. College of Cardiology 1996 30. Ramo MP, Spencer T, Sutherland GR, Salter DM, Kearney P, Lamb D, Shaw TRD, McDicken WN. Can Radiofrequency data analysis of intravascular ultrasound accurately differentiate sonolucent coronary atherosclerotic plaques? ESC meeting, Birmingham 1996. 31. Moore (Ramo) MP, Spencer T, Sutherland GR, Kearney, PP, Mcdicken WN, Fox KAA. Identification of intramural lipid by spectral analysis of IVUS radiofrequency data. European Society of Cardiology, 1997 32. Moore MP. Sonotherapy reduces significantly the amount of intimal hyperplasia after vessel wall injury. 6th International LDDD R, Geneva, Switzerland, 2000 33. Fitzgerald PJ, Moore MP, Hayase M, Takagi A, Kolodgie FD, Corl PD, Nassi M, Virmani R. Intravascular sonotherapy impacts neointimal hyperplasia following stent implantation in swine femoral arteries. Suppl J ACC, February 2000. vol 35, issue 2, suppl A, 28 34. Post M, Moore MP, Nassi M, Bao J, Virmani R, Kolodgie F, Corl D, Kuntz R. Intravascular Sonotherapy Prevents intimal Hyperplasia in a coronary Stent Pig Model without long term adverse effects. AHA, New Orleans, 2000 35. Moore MP Virmani R, Kuntz R, Fitzgerald PJ, Corl PD, Kolodgie FD, Nassi M, Yock PG. Intravascular sonotherapy (ISY) reduces intimal hyperplasia in stented swine coronary arteries. European Society of Cardiology Annual Meeting, Amsterdam 2000 (one of five best abstracts selected by the ESC) 36. D. Böse, A. Schmermund, P. Margolis, A. Nair, D.G. Vince, J. Rodermann, W. Wijns, R. Erbel. Plaquezusammensetzung in Abhängigkeit von Risikofaktoren: In-vivo Analyse mittels Virtueller Histologie auf der Basis des Radiofrequenzdatensatzes des intravaskulären Ultraschalls. DGK 2004 37. D. Böse, A. Schmermund, P. Margolis, A. Nair, D.G. Vince, H.Eggebrecht, C.Naber, R. Erbel. Intravascular Ultrasound Radiofrequency Analysis Identifies Plaque Composition: Virtual Histology. ESC. 2004. 10
Reviews and Book Chapters 1. Rämö P, Kettunen R and Hirvonen L. Hemodynamic effects of endurance training on canine left ventricle. Year Book of Cardiology, Chapter 1, pp 19-20. Ed Schlant RC, Year Book Med Pub Inc, Chicago, USA. 1988. 2. Rämö OJ, Rämö MP, Huusari H, Mokka REM ja Mattila S. Verisuonten tähystystulevaisuuden menetelmä sydän – ja verisuonisairauksien diagnostiikassa ja hoidossa. Duodecim 1993;109:1661-1666. 3. Rämö MP. Karvediloli – uusi vaihtoehto hypertonian hoitoon. Suomen Lääkärilehti 1994. 4. Kearney PP, Ramo MP, Spencer T, Shaw TRD, Starkey I, Sutherland GR. Ambiguities and artifacts in intravascular ultrasound imaging: a comprehensive review 1995 5. Ramo P and Spencer T. Tissue characterization. R Erbel (Ed.) in: An Atlas for Intravascular Ultrasound. Martin Ownitz Publishers: London, 1997. 6. Margolis, MP. Volcano Therapeutics. Handbook of the Vulnerable Plaque. Ed R Waksman and P Serruys. Martin Dunitz (NY) 2004. 7. Mastering Endovascular Techniques: A Guide to Excellence, by Peter Lenzer. Published by Lippincott, Williams and Wilkins 2007.
Invited Lecturer at international cardiology meetings globally 1995 – Present American College of Cardiology American Heart Meeting Transcatheter Technology Meeting (TCT) TCT – Asia Snowmass Annual Meeting PCR Meeting (Europe) CRT JSECT ICI European Society of Cardiology
Professional Membership American College of Cardiology European Society of Cardiology Co-Chair- Women’s Heart Health Matters